Partially Saturated Bicyclic Heteroaromatics as an sp3 -Enriched Fragment Collection
نویسندگان
چکیده
منابع مشابه
Partially Saturated Bicyclic Heteroaromatics as an sp3‐Enriched Fragment Collection
Fragment-based lead generation has proven to be an effective means of identifying high-quality lead compounds for drug discovery programs. However, the fragment screening sets often used are principally comprised of sp(2) -rich aromatic compounds, which limits the structural (and hence biological) diversity of the library. Herein, we describe strategies for the synthesis of a series of partiall...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2016
ISSN: 1433-7851
DOI: 10.1002/anie.201606496